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Concurrently, it activates the HOXA9/MENIN pathway to upregulate the expression of key enzymes in the serine synthesis pathway and boost endogenous serine production, thereby remodeling serine metabolism and driving leukemogenesis ( The expression patterns characterized by high expression of only one or two enzymes in these cancer types may stem from the unique demand for carbon source diversion from upstream glycolysis in corresponding tumors
E., Weeraratna, A
doi: 10.1089/ars.2013.5346 69 NakanoMImamuraHSasaokaNYamamotoMUemuraNShudoTet al
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